Stress May Amplify Malignant Skin Cancer Growth

An innovative study by US medical researchers at(IBMR), and Ronald Glaser, a professor of molecular
the Ohio State University (OSU) has revealed thatvirology, immunology and medical genetics observed
stress amplifies the progression of malignanteffects of stress hormone, norepinephrine on three
melanoma, a particular form of skin cancer. Malignantdifferent types of proteins released by melanoma
melanoma is one of the most deadly forms of skincells -1) Vascular endothelial growth factor (VEGF); 2)
cancer that is becoming increasingly commonInterleukin-6 and; 3) Interleukin-8 all proteins active in
worldwide.growth of tumors.
After two years of research, medical researchersThe three malignant tumor cells lines, i.e. VEGF,
came to a conclusion that there is a link betweenintereleukin-6 and interleukin-8, were introduced to
stress hormones and cancer. The stress hormone,the norepinephrine and all the three showed increase
norepinephrine also known as "flight or fight"in levels expressed, particularly in the most advanced
hormone, produces enzyme that stimulates bloodline which showed a 2000 percent increase in levels
vessels to grow in melanoma tumors, acceleratingof interleukin-6 thus establishing the fact that stress
the progression and spread of tumors, thehas worse effect on aggressive and advanced stage
researchers explained. These findings were publishedmalignant melanoma.
in the February 2009 issue of the journal Brain,The researchers believe their findings would help slow
Behavior and Immunity.down the progression of malignant melanoma and
A research team including Eric V. Yang a researchoffer new hope for prolonging the lives of patients
scientist at Institute for Behavioral Medicine Researchsuffering with advanced stage malignant melanoma.